• Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia 

      Watts, Eleanor L.; Perez-Cornago, Aurora; Fensom, Georgina K.; Smith-Byrne, Karl; Noor, Urwah; Andrews, Colm D.; Gunter, Marc J.; Holmes, Michael V.; Martin, Richard M.; Tsilidis, Konstantinos K.; Albanes, Demetrius; Barricarte, Aurelio; Bueno-de-Mesquita, Bas; Chen, Chu; Cohn, Barbara A.; Dimou, Niki L.; Ferrucci, Luigi; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward L.; Goodman, Gary E.; Haiman, Christopher A.; Hankey, Graeme J.; Huang, Jiaqi; Huang, Wen-Yi; Hurwitz, Lauren M.; Kaaks, Rudolf; Knekt, Paul; Kubo, Tatsuhiko; Langseth, Hilde; Laughlin, Gail; Le Marchand, Loic; Luostarinen, Tapio; MacInnis, Robert J.; Mäenpää, Hanna O.; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Mucci, Lorelei A.; Olsen, Anja; Ozasa, Kotaro; Palli, Domenico; Penney, Kathryn L.; Platz, Elizabeth A.; Rissanen, Harri; Sawada, Norie; Schenk, Jeannette M.; Stattin, Pär; Tamakoshi, Akiko; Thysell, Elin; Tsai, Chiaojung Jillian; Tsugane, Shoichiro; Vatten, Lars Johan; Weiderpass, Elisabete; Weinstein, Stephanie J.; Wilkens, Lynne R.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-17)
      Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate ...
    • Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: a Prospective Study and Meta-Analysis 

      Mori, Nagisa; Keski-Rahkonen, Pekka; Gicquiau, Audrey; Rinaldi, Sabina; Dimou, Niki; Harlid, Sophia; Harbs, Justin; Van Guelpen, Bethany; Aune, Dagfinn; Cross, Amanda J.; Tsilidis, Konstantinos K.; Severi, Gianluca; Kvaskoff, Marina; Fournier, Agnès; Kaaks, Rudolf; Fortner, Renée Turzanski; Schulze, Matthias B.; Jakszyn, Paula; Sánchez, Maria-José; Colorado-Yohar, Sandra M.; Ardanaz, Eva; Travis, Ruth; Watts, Eleanor L.; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Buenode-Mesquita, bas; Gram, Inger Torhild; Waaseth, Marit; Gunter, Marc J.; Murphy, Neil (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Background - Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results.<p> <p>Methods - We investigated the associations between circulating concentrations ...
    • Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer 

      Mukama, Trasias; Fortner, Renée Turzanski; Katzke, Verena; Hynes, Lucas Cory; Petrera, Agnese; Hauck, Stefanie M.; Johnson, Theron; Schulze, Matthias; Schiborn, Catarina; Rostgaard-Hansen, Agnetha Linn; Tjønneland, Anne; Overvad, Kim; Pérez, María José Sánchez; Crous-Bou, Marta; Chirlaque, María-Dolores; Amiano, Pilar; Ardanaz, Eva; Watts, Eleanor L.; Travis, Ruth C.; Sacerdote, Carlotta; Grioni, Sara; Masala, Giovanna; Signoriello, Simona; Tumino, Rosario; Gram, Inger Torhild; Sandanger, Torkjel M; Sartor, Hanna; Lundin, Eva; Idahl, Annika; Heath, Alicia K.; Dossus, Laure; Weiderpass, Elisabete; Kaaks, Rudolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-14)
      BACKGROUND: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.<p> <p>METHODS: In the European Prospective Investigation into Cancer and Nutrition ...
    • Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition 

      Heath, Alicia K; Clasen, Johanna L; Jayanth, Nick P; Jenab, Mazda; Tjønneland, Anne; Petersen, Kristina E N; Overvad, Kim; Srour, Bernard; Katzke, Verena; Bergmann, Manuela M; Schulze, Matthias B; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Catalano, A; Pasanisi, Fabrizio; Brustad, Magritt; Olsen, Karina Standahl; Skeie, Guri; Lujan-Barroso, Leila; RodrÍguez-Barranco, Miguel; Amiano, Pilar; Santiuste, Carmen; Gurrea, Aurelio Barricarte; Axelson, Håkon; Ramne, Stina; Ljungberg, Börje; Watts, Eleanor L.; Huybrechts, Inge; Weiderpass, Elisabete; Riboli, Elio; Muller, David C (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-01)
      Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and ...